Albendazole is an antiprotozoal and anthelmintic drug from the benzimidazole carbomate group. The drug acts on both intestinal and tissue parasites in the form of eggs, larvae and adult helminths. The anthelmintic effect of albendazole is the result of inhibition of tubulin polymerization, which leads to metabolic disorders and death of helminths.
Albendazole destroys cysts or significantly reduces their size (up to 80%) in patients with granular echinococcosis. After treatment with albendazole, the number of nonviable cysts increases to 90% compared with 10% in patients who did not undergo treatment. After the use of albendazole for the treatment of cysts caused by Echinococcus multilocularis, complete recovery was observed in a minority of patients, and in the majority - improvement or stabilization of the condition.
Indications for use
Intestinal forms of helminthiasis and cutaneous syndrome Larva Migrans (short-term treatment with low doses): enterobiasis, hookworm and necatoriasis, hymenolepidosis, teniasis, strongyloidiasis, ascariasis, trichocephalosis, clonorchiasis, opisthorchiasis, cutaneous syndrome Larva Migrans, giardiasis in children.
Systemic helminth infections (long-term treatment with high doses):
cystic echinococcosis (caused by Echinococcus granulosus):
if surgical intervention is not possible before surgical intervention after surgery, if preoperative treatment was short, if helminths are disseminated or live forms were found during surgery; after percutaneous drainage of cysts for diagnostic or therapeutic purposes;
Alveolar echinococcosis (caused by Echinococcus multilocularis):
in inoperable disease, particularly in cases of local or distant metastases; after palliative surgery after radical surgery or liver transplantation
Neurocysticercosis (caused by Taenia solium larvae):
in the presence of single or multiple cysts or in granulomatous brain lesions in arachnoid or intraventricular cysts; in racemose cysts;
capillarosis (caused by Capillaria philippinensis), gnathostomiasis (caused by Gnathostoma spinigerum and related species), trichinosis (caused by Trichinella spiralis and T.pseudospiralis), toxocariasis (caused by Toxocara canis and related species).
Contraindication
Hypersensitivity to albendazole or to any component of the drug.
Pregnancy and breastfeeding.
Women planning pregnancy: Women of childbearing potential should use effective non-hormonal contraceptives during and for 1 month after treatment.
Special instructions
Use during pregnancy or breastfeeding
The drug is contraindicated for use during pregnancy and breastfeeding and for the treatment of women planning a pregnancy.
Children
The drug is contraindicated in children under 1 year of age.
The ability to influence the reaction speed when driving vehicles or other mechanisms.
Given the presence of such a side effect as dizziness, it is recommended to refrain from driving and operating machinery during the period of use of albendazole.
Method of administration and doses
Intestinal forms and cutaneous syndrome of Larva Migrans
Take the drug with food. Shake before use. It is advisable to use at the same time of day. If recovery does not occur after 3 weeks, the doctor should prescribe a second course of treatment.
| infection | age | Dose and duration of use |
| Enterobiasis, hookworm, necrosis, ascariasis, trichocephalosis | Adults and children aged 2 years and over | 400 mg / 1 time per day (10 ml of suspension) once. |
| Children aged 1 to 2 years | 200 mg / 1 time per day (5 ml of suspension) once. |
| Strongyloidiasis, taeniasis, hymenolepiasis | Adults and children aged 2 years and over | 400 mg / 1 time per day (10 ml of suspension) for 3 days. In case of hymenolepidosis, a repeated course of treatment is recommended in the interval from the 10th to the 21st day after the previous course. |
| Clonorchiasis, opisthorchiasis | Adults and children aged 2 years and over | 400 mg (10 ml of suspension) 2 times a day for 3 days. |
| Cutaneous Larva Migrans Syndrome | Adults and children aged 2 years and over | 400 mg (10 ml of suspension) once a day for 1-3 days. |
| giardiasis | Only children aged 2 to 12 years old | 400 mg (10 ml of suspension) once a day for 5 days. |
For body weight less than 60 kg, the drug should be administered at the rate of 15 mg/kg/day. This dose should be divided into 2 doses. The maximum daily dose is 800 mg.
Overdose
In case of overdose, treatment is symptomatic, according to the clinical condition.
Composition
active ingredient: albendazole;
10 ml of suspension contain 400 mg of albendazole;
Excipients: aluminum-magnesium silicate, sodium carboxymethylcellulose, glycerin, polysorbate 80, sorbitan laurate, potassium sorbate, benzoic acid, sorbic acid, antifoam silicone 1510, sodium saccharin, orange flavor, vanilla flavor, intensely fruit flavor, purified water.
Storage conditions
Store below 25°C. Keep out of reach of children. Protect from direct sunlight. Shake before use.
Shelf life - 3 years.
